Sickle cell gene is believed to have evolved as a response to malaria

The sickle cell gene is believed to have evolved as a protective response to malaria, which is why it is more prevalent in populations from malaria-endemic regions. Therefore, while sickle cell disease is rare in white populations, it is possible for white people to have the disease or carry the trait.

The sickle cell trait (SCT) protects against malaria through a combination of biochemical and immune-mediated mechanisms, primarily by disrupting the Plasmodium falciparum parasite’s life cycle and enhancing host defenses.

Source: Perplexity https://www.perplexity.ai/search/does-sickle-cell-disease-affec-MGB7IJ_0RrGZJUoSSVNpvA